Understanding how breast cells grow and produce milk
Notch/Robo Regulated Mechanisms Governing Cell Fate Acquisition
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA SANTA CRUZ · NIH-10755724
This study is looking at how certain stem cells in the breast grow and change during pregnancy to help them produce milk, especially when there’s DNA damage involved, and it hopes to find ways to better support women who have trouble with milk supply.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA SANTA CRUZ (nih funded) |
| Locations | 1 site (SANTA CRUZ, UNITED STATES) |
| Trial ID | NIH-10755724 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that control the growth and differentiation of specific stem cells in the breast, particularly during pregnancy. It aims to uncover how these cells become capable of producing milk, focusing on the role of signaling pathways that respond to DNA damage. By studying how cells undergo a process called endoreplication, which is essential for milk production, the research seeks to fill a critical knowledge gap that affects many women. The findings could lead to better support for those who struggle with milk supply issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant or lactating women who may have concerns about their milk production.
Not a fit: Patients who are not pregnant or lactating, or those who do not have issues with milk supply, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve milk production in women who experience insufficient milk supply.
How similar studies have performed: Other research has shown promising results in understanding cell signaling pathways related to growth and differentiation, making this approach both relevant and potentially impactful.
Where this research is happening
SANTA CRUZ, UNITED STATES
- UNIVERSITY OF CALIFORNIA SANTA CRUZ — SANTA CRUZ, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HINCK, LINDSAY E — UNIVERSITY OF CALIFORNIA SANTA CRUZ
- Study coordinator: HINCK, LINDSAY E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.