Understanding how breast cancer spreads to bones
Official title: Decipher the Molecular Mechanisms of Breast Cancer Bone Metastasis
Funded at Roswell Park Cancer Institute Corp · NIH-11130206 · Data updated 2026-11-12
This study is looking at how breast cancer spreads to the bones and aims to find new ways to treat it, so patients can have better options for managing this serious issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $700,690 |
| NIH project number | 1R01CA292730-01A1 |
| Project ID | NIH-11130206 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with advanced breast cancer who are experiencing or at risk of bone metastases.
✕Less likely to help
Patients with early-stage breast cancer or those without bone involvement may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms by which breast cancer cells metastasize to bone, which is a common and serious complication of advanced breast cancer. The study aims to identify new therapeutic strategies that can effectively target and eradicate cancer cells in the bone environment, rather than just managing bone health. By examining the transition from early microscopic bone metastases to established ones, the research seeks to uncover critical biological behaviors and metabolic processes involved in this progression. Patients may benefit from insights that could lead to improved treatments for managing bone metastases and preventing cancer spread.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with breast cancer that has spread to the bones, potentially reducing pain and improving quality of life.
How similar studies have gone: Previous research has shown promise in targeting metastatic processes in other cancers, but this specific approach to breast cancer bone metastasis is relatively novel.
Where this research is happening
-
Roswell Park Cancer Institute Corp
Buffalo, United States Active
Researchers
- Principal investigator: Wang, Hai — Roswell Park Cancer Institute Corp
- Study coordinator: Wang, Hai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.