Understanding how breast cancer spreads to bones
Spatiotemporal modeling of cancer-niche interactions in breast cancer bone metastasis
['FUNDING_U01'] · METHODIST HOSPITAL RESEARCH INSTITUTE · NIH-10923871
This study is looking at how breast cancer cells behave in the bones after the main tumor is removed, especially in the early stages of spreading, to find ways to stop them from growing there and help improve treatment options for patients.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | METHODIST HOSPITAL RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10923871 on ClinicalTrials.gov |
What this research studies
This research investigates how breast cancer cells interact with the bone environment, particularly focusing on the early stages of bone metastasis that occur years after the primary tumor is removed. By examining the different niches within the bone, such as the perivascular and osteogenic areas, the study aims to uncover the mechanisms that allow cancer cells to survive and potentially grow in these locations. Advanced imaging techniques will be used to visualize these interactions and identify potential therapeutic targets to prevent the progression of metastasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are breast cancer patients who are at risk of developing bone metastasis, particularly those who have undergone surgery for primary tumors.
Not a fit: Patients who do not have breast cancer or those whose cancer has already progressed to advanced metastatic stages may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent breast cancer from spreading to the bones, improving patient outcomes.
How similar studies have performed: Other research has shown promise in understanding cancer metastasis through similar approaches, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
HOUSTON, UNITED STATES
- METHODIST HOSPITAL RESEARCH INSTITUTE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WONG, STEPHEN TC — METHODIST HOSPITAL RESEARCH INSTITUTE
- Study coordinator: WONG, STEPHEN TC
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.