Understanding how breast cancer spreads in 3D environments
RTB 2
This study is looking at how breast cancer spreads in the body, using special 3D models to watch how cancer cells behave, with the hope of finding new ways to stop or treat the spread of the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10994094 on NIH RePORTER |
What this research studies
This research investigates the complex process of breast cancer metastasis, which is the spread of cancer cells from the original tumor to other parts of the body. By using innovative 3D assays, the team models each step of metastasis outside of the body, allowing for real-time imaging and analysis of cell behavior and interactions within the tumor microenvironment. The goal is to identify key molecular signals that can be targeted for new therapies to prevent or treat metastatic breast cancer. This approach aims to provide a more comprehensive understanding of how cancer cells invade blood vessels and transition to metastatic disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those at risk of or experiencing metastasis.
Not a fit: Patients with non-breast cancer types or those who are not currently undergoing treatment for breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that effectively target and prevent breast cancer metastasis, potentially improving survival rates.
How similar studies have performed: Previous research has shown promise in using 3D modeling approaches to study cancer behavior, indicating that this innovative method could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Ewald, Andrew Josef — Johns Hopkins University
- Study coordinator: Ewald, Andrew Josef
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.