Understanding how breast cancer spreads and resists treatment
Official title: Evolutionary dynamics and microenvironmental determinants of metastatic breast cancer
Funded at Stanford University · NIH-10977547 · Data updated 2026-11-12
This study is looking at how breast cancer spreads and why some treatments don't work, using special lab models and samples from patients to find new ways to improve care for those with breast cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 14, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $62,921 |
| NIH project number | 3U54CA261719-04S1 |
| Project ID | NIH-10977547 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with metastatic breast cancer who are undergoing treatment.
✕Less likely to help
Patients with early-stage breast cancer or those who do not have a diagnosis of breast cancer may not benefit from this research.
What this research studies
This research investigates the factors that contribute to the spread of breast cancer and its resistance to therapies. It focuses on understanding the timing of when cancer cells metastasize and how interactions between cancer cells and their surrounding environment influence this process. The study utilizes advanced computational models and a unique collection of patient-derived organoids to explore the complexities of breast cancer behavior and treatment responses. By analyzing these models and patient samples, the research aims to uncover new insights that could lead to improved treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for metastatic breast cancer, potentially improving survival rates and quality of life for patients.
How similar studies have gone: Previous research has shown promise in understanding cancer metastasis and treatment resistance using similar approaches, indicating a potential for success in this area.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Curtis, Christina N — Stanford University
- Study coordinator: Curtis, Christina N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.