Understanding how breast cancer progresses and resists treatment
Project 3: Systematic characterization of factors controlling breast cancer progression and resistance
['FUNDING_OTHER'] · STANFORD UNIVERSITY · NIH-11178841
This study is looking at how breast cancer grows and becomes resistant to treatments, using special lab models to find out which genes help the cancer avoid the immune system and come back after therapy, with the goal of creating better, personalized treatment options for patients like you.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11178841 on ClinicalTrials.gov |
What this research studies
This research investigates the factors that contribute to the progression of breast cancer and its resistance to therapies. By utilizing advanced 3D cell culture models that mimic the tumor environment, the team aims to identify key genetic regulators involved in immune evasion and therapeutic relapse. The study employs CRISPR technology to manipulate genes in these models, allowing researchers to pinpoint which genes drive resistance in specific subgroups of breast cancer. This approach could lead to more effective treatment strategies tailored to individual patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with metastatic breast cancer, especially those with estrogen receptor-positive subtypes that have a high risk of relapse.
Not a fit: Patients with non-breast cancer conditions or those with early-stage breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for breast cancer patients, particularly those at high risk of relapse.
How similar studies have performed: Previous research using similar 3D culture models and CRISPR technology has shown promising results in understanding cancer biology and treatment resistance.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BASSIK, MICHAEL C — STANFORD UNIVERSITY
- Study coordinator: BASSIK, MICHAEL C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Breast Cancer Cell, Breast Cancer Risk Factor