Understanding how breast cancer cells spread
Mechanisms of linkage of stem and invasive phenotypes during metastatic colonization
This research aims to understand how certain breast cancer cells become highly aggressive and spread to other parts of the body.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11126055 on NIH RePORTER |
What this research studies
We are learning more about a special type of breast cancer cell that can resist chemotherapy and easily travel throughout the body. These cells have unique features, including a protein called MenaINV and stem cell-like qualities, which help them leave the original tumor and grow in new places. We are also exploring how immune cells called macrophages and even chemotherapy might encourage these aggressive cells to emerge. Our goal is to uncover the exact steps these cells take to spread, which is the main reason breast cancer becomes life-threatening.
Who could benefit from this research
Good fit: This foundational research is relevant for patients with breast cancer, especially those at risk of or experiencing metastatic disease.
Not a fit: Patients without breast cancer or those whose cancer has not shown signs of metastasis may not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to new ways to stop breast cancer from spreading, improving treatment outcomes for patients.
How similar studies have performed: This research builds upon previous findings about specific cancer cell behaviors and introduces novel insights into the role of MenaINV and stem cell programs in metastasis.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Oktay, Maja Hrzenjak — Albert Einstein College of Medicine
- Study coordinator: Oktay, Maja Hrzenjak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.