Understanding how breast cancer cells grow without estrogen
Mechanism of estrogen independent proliferation in ER+ breast cancer cells
This study is looking into how certain breast cancer cells can grow without needing estrogen, which could help find new ways to treat early-stage breast cancer for patients like you.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-10977525 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the growth of estrogen receptor-positive breast cancer cells that do not rely on estrogen for proliferation. By analyzing tumor biopsies and using advanced techniques like single-cell transcriptomic profiling, the study aims to uncover how these cancer cells adapt and resist treatments. The researchers will explore the role of specific proteins and pathways that may contribute to this resistance, particularly focusing on the interaction between cell cycle regulators and estrogen signaling. This could lead to better treatment strategies for patients with early-stage breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with early-stage estrogen receptor-positive breast cancer.
Not a fit: Patients with estrogen receptor-negative breast cancer or those with advanced metastatic disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with estrogen receptor-positive breast cancer, particularly those in earlier stages of the disease.
How similar studies have performed: Previous research has shown promising results in combining CDK inhibitors with endocrine therapy for metastatic breast cancer, suggesting potential for success in earlier stages as well.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Nath, Aritro — Beckman Research Institute/city of Hope
- Study coordinator: Nath, Aritro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.