Understanding how breast cancer cells grow without estrogen

Who could benefit from this research

What this research studies

This research investigates the mechanisms behind the growth of estrogen receptor-positive breast cancer cells that do not rely on estrogen for proliferation. By analyzing tumor biopsies and using advanced profiling techniques, the study aims to identify how certain pathways, like the JNK MAPK pathway, contribute to cancer cell resistance against treatments. The researchers will explore the interactions between cell cycle regulators and estrogen signaling to better understand how these tumors can reactivate and proliferate despite therapy. This could lead to more effective treatment strategies for patients with early-stage breast cancer.

Why it matters

Where this research is happening

• Beckman Research Institute/city of Hope
  Duarte, United States Active

Researchers

• Principal investigator: Nath, Aritro — Beckman Research Institute/city of Hope
• Study coordinator: Nath, Aritro

Related research

Other NIH-funded projects on the same topics.

• ER+ Breast Cancer Bone Metastasis in a Real Body Environment

  This grant aims to understand why estrogen receptor alpha–positive breast cancer often spreads to bone and how the bone environment and immune system affect treatment resistance.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11422333

• Targeting RAGE to fight obesity-related ER+ breast cancer and its drug resistance

  A scientist team will explore how obesity-related inflammation involving RAGE and estrone interacts with ER+ breast cancer to drive growth and spread, aiming to find strategies to overcome therapy resistance.

  NIH research Georgetown University · Washington, United States · NIH-11364105

• Understanding estrogen signals in bone to stop ER+ breast cancer spread

  This NIH grant aims to uncover how estrogen signals inside bone help ER-positive breast cancer cells grow and spread, with the goal of finding better ways to prevent bone metastasis.

  NIH research University of Arizona · Tucson, United States · NIH-11364029

• Progesterone Receptor Signaling and Dormancy in ER+ Breast Cancer

  Researchers are studying how hormone signals in ER+/PR+ breast cancer influence cancer cell dormancy and later recurrence.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11363974

• Heavy Metals and Breast Cancer Treatment Resistance

  This project explores how exposure to heavy metals might make ER+ breast cancer harder to treat and how we might overcome this challenge.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11349797

• Turning ER-positive breast cancer into a viral target for immune attack

  This project aims to wake up viral-like bits inside ER-positive breast cancer cells so the immune system can spot and attack them.

  NIH research Sanford Burnham Prebys Medical Discovery Institute · La Jolla, United States · NIH-11308203

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.