Understanding how breast cancer cells grow and return after treatment
In Vivo Oncogene-Induced Tumorigenesis and Escape
This work aims to uncover why breast cancer sometimes comes back after treatment, even years later, to help prevent its return.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11145884 on NIH RePORTER |
What this research studies
Many breast cancer patients face the challenge of their cancer returning, which is often difficult to cure. This happens because some cancer cells can remain hidden in the body, in a 'dormant' state, long after initial treatment. Our goal is to understand how these hidden cells survive and what causes them to wake up and cause new tumors. By learning more about these processes, we hope to find ways to eliminate these lingering cells and stop the cancer from coming back.
Who could benefit from this research
Good fit: This foundational research is relevant for all patients who have been treated for breast cancer, especially those concerned about recurrence.
Not a fit: Patients without a history of breast cancer would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that prevent breast cancer from recurring, significantly improving long-term survival for patients.
How similar studies have performed: Previous work using advanced mouse models has already identified specific biological pathways linked to dormant cancer cells and recurrence risk in patients, suggesting a promising direction.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Chodosh, Lewis a — University of Pennsylvania
- Study coordinator: Chodosh, Lewis a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.