Understanding how BRD8 affects hormone receptor-positive and HER2-positive breast cancer
Functions of BRD8 in HR+/HER2+ breast cancer
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11095727
This study is looking into how a protein called BRD8 affects breast cancer that is both hormone receptor-positive and HER2-positive, to find out why some patients don’t respond well to current treatments and to discover new ways to help them feel better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11095727 on ClinicalTrials.gov |
What this research studies
This research investigates the role of BRD8 in breast cancer that is both hormone receptor-positive and HER2-positive. It aims to understand why some patients with this type of cancer do not respond well to existing HER2-targeted therapies. By using advanced techniques like single cell RNA sequencing, the study explores the interactions between hormone and HER2 signaling pathways. The goal is to identify new therapeutic strategies that could improve treatment outcomes for these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with hormone receptor-positive and HER2-positive breast cancer.
Not a fit: Patients with HER2-negative breast cancer or those without hormone receptor involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with HR+/HER2+ breast cancer.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in breast cancer, indicating potential for success in this approach.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XU, WEI — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: XU, WEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.