Understanding how BRD8 affects hormone receptor-positive and HER2-positive breast cancer

Who could benefit from this research

What this research studies

This research investigates the role of BRD8 in breast cancer that is both hormone receptor-positive and HER2-positive. It aims to understand why some patients with this type of cancer do not respond well to existing HER2-targeted therapies. By using advanced techniques like single cell RNA sequencing, the study explores the interactions between hormone and HER2 signaling pathways. The goal is to identify new therapeutic strategies that could improve treatment outcomes for these patients.

Why it matters

Where this research is happening

• University of Wisconsin-Madison
  Madison, United States Active

Researchers

• Principal investigator: Xu, Wei — University of Wisconsin-Madison
• Study coordinator: Xu, Wei

Related research

Other NIH-funded projects on the same topics.

• BRD8's role in hormone-receptor positive, HER2-positive breast cancer

  This project looks at whether targeting a protein called BRD8 can help people with hormone-receptor positive, HER2-positive breast cancer respond better to HER2 treatments.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11284108

• Targeting lipid metabolism to improve treatment for HER2+ breast cancer that has spread to the brain

  This study is looking at how to make treatments work better for people with HER2 positive breast cancer that has spread to the brain by finding ways to block the cancer cells' use of fats to grow, which could help existing therapies be more effective.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11079642

• Improving Breast Cancer Guideline Adherence in Nigeria

  Aimed at helping doctors in Nigeria follow international guideline-based breast cancer care to improve outcomes for women with breast cancer.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11625517

• Genomic study to understand how genetics and epigenetics shape triple-negative breast cancer in African ancestry

  This study looks at how inherited genes and gene activity affect triple-negative breast cancer in people of African ancestry to better understand why outcomes can be worse.

  NIH research Tuskegee University · Tuskegee Institute, United States · NIH-11621786

• Translational breast cancer research to improve treatment options

  A comprehensive program at Baylor College of Medicine is focusing on breast cancer; researchers will advance targeted therapies and biomarkers to help patients with aggressive or hard-to-treat forms.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11616352

• Cancer Pain Management for Asian American Breast Cancer Survivors with Depressive Symptoms

  A technology-based program helps Asian American breast cancer survivors with depressive symptoms manage chronic pain more effectively from home using a web app and mobile tools.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11609950

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.