Understanding how BRCA2 mutations affect prostate cancer treatment responses
Elucidating mechanisms of therapy response in BRCA2 mutant prostate cancers
['FUNDING_FELLOWSHIP'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10881665
This study is looking at why some prostate cancers with BRCA2 mutations don’t respond well to treatment and how we can improve those treatments, specifically for patients with advanced castrate-resistant prostate cancer.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10881665 on ClinicalTrials.gov |
What this research studies
This research investigates the biological mechanisms behind therapy resistance in prostate cancers with BRCA2 mutations, particularly focusing on the effectiveness of PARP inhibitors. By utilizing new patient-derived models, the study aims to uncover how these cancers adapt to treatment and develop resistance. Patients with advanced castrate-resistant prostate cancer (CRPC) will be studied to identify potential strategies to enhance treatment responses and overcome resistance. The research employs advanced sequencing techniques and analysis of gene expression to understand the underlying biological changes.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with advanced castrate-resistant prostate cancer who have pathogenic BRCA2 mutations.
Not a fit: Patients without BRCA2 mutations or those with early-stage prostate cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with BRCA2 mutant prostate cancers, potentially enhancing their response to therapies.
How similar studies have performed: Previous research has shown promising results in understanding therapy resistance in similar cancer types, indicating that this approach could yield valuable insights.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOFSTAD, MIA E — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: HOFSTAD, MIA E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.