Understanding How BRCA2 and Related Proteins Repair DNA to Prevent Cancer
Molecular Functions of BRCA2 and RAD51 Paralogs in Homologous Recombination and Chromosome Maintenance
This work helps us learn how specific proteins, like BRCA2, fix DNA damage in our bodies and how problems with these proteins can lead to cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11136269 on NIH RePORTER |
What this research studies
Our bodies have natural repair systems to fix damaged DNA, and proteins like BRCA2 are key players in this process. When these proteins don't work correctly, DNA damage can build up, increasing the risk of developing certain cancers. This project aims to uncover the exact steps these proteins take to repair DNA, looking closely at how they interact and function. We will also examine how specific changes in these proteins, found in patients, affect their ability to do their job. By understanding these fundamental processes, we hope to gain insights into why some people are more prone to cancer.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals with inherited mutations in BRCA2 or related genes, who have an increased risk for certain cancers.
Not a fit: Patients whose cancers are not linked to defects in BRCA2 or related DNA repair pathways may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of cancer development and potentially inspire new strategies for prevention or treatment, especially for individuals with genetic predispositions.
How similar studies have performed: Extensive prior research has established the critical role of BRCA2 and homologous recombination in DNA repair and cancer prevention, providing a strong foundation for this work.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Kowalczykowski, Stephen Charles — University of California at Davis
- Study coordinator: Kowalczykowski, Stephen Charles
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.