Understanding how BRCA2 and RAD51 proteins repair DNA damage
Homology-directed repair: BRCA2 and RAD51 paralogs
This study is looking at how certain proteins, BRCA2 and RAD51, help fix DNA and keep our genes healthy, especially in people with breast and ovarian cancer, to see how changes in these proteins might affect how well cancer treatments work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10897972 on NIH RePORTER |
What this research studies
This research investigates the role of homologous recombination, a key DNA repair process, particularly focusing on the proteins BRCA2 and RAD51. It aims to understand how these proteins maintain genomic stability and how their dysfunction can lead to cancer, especially in breast and ovarian cancers. The study will analyze how mutations in these proteins affect the response to cancer treatments like cisplatin and PARP inhibitors. By exploring the mechanisms of DNA repair, the research seeks to identify potential strategies to restore the function of these proteins in cancer cells.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with breast or ovarian cancer who have mutations in the BRCA2 gene or related HDR proteins.
Not a fit: Patients without BRCA2 mutations or those with cancers unrelated to homologous recombination may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments and better outcomes for patients with BRCA2-related cancers.
How similar studies have performed: Previous research has shown promising results in targeting DNA repair mechanisms in cancer treatment, indicating that this approach could be effective.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Jasin, Maria — Sloan-Kettering Inst Can Research
- Study coordinator: Jasin, Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.