Understanding how BRCA2 and 53BP1 interact in DNA repair
Official title: Project 3: Antagonistic Mechanisms of BRCA2 and the 53BP1 Axis in RAD51 Nucleoprotein Filament Assembly
Funded at University of Texas Hlth Science Center · NIH-10847790 · Data updated 2026-11-12
This study is looking at how two important proteins, BRCA2 and 53BP1, help fix DNA damage, which could lead to better treatments for breast cancer by improving our understanding of how these processes work.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $541,923 |
| NIH project number | 1P01CA275717-01A1 |
| Project ID | NIH-10847790 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of breast cancer or those who carry mutations in the BRCA1 or BRCA2 genes.
✕Less likely to help
Patients without a genetic predisposition to breast cancer or those not affected by DNA repair deficiencies may not benefit from this research.
What this research studies
This research investigates the mechanisms by which BRCA2 and 53BP1 regulate the repair of DNA damage, specifically focusing on how these proteins influence the assembly of RAD51, a key component in the DNA repair process. By examining the interactions and functions of these proteins, the research aims to uncover new insights into the homology-directed repair pathway, which is crucial for maintaining genomic stability. Patients may benefit from this research as it could lead to improved understanding of breast cancer mechanisms and potential new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could enhance treatment options for patients with breast cancer by providing insights into DNA repair mechanisms.
How similar studies have gone: Previous research has shown promising results in understanding DNA repair mechanisms, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Mazin, Alexander V — University of Texas Hlth Science Center
- Study coordinator: Mazin, Alexander V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.