Understanding how BRCA2 affects the formation of sperm and eggs
Official title: Roles of BRCA2 in Mammalian Meiosis and Gamete Quality
Funded at University of California at Davis · NIH-11021019 · Data updated 2026-11-12
This study is looking at how a protein called BRCA2 helps with the creation of sperm and eggs, which is important for having healthy babies, and it aims to find out how this protein affects DNA repair and the way chromosomes are sorted during cell division.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | February 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $683,926 |
| NIH project number | 5R01HD109322-02 |
| Project ID | NIH-11021019 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of breast cancer or known BRCA2 mutations who are concerned about their reproductive health.
✕Less likely to help
Patients without any known genetic predisposition to breast cancer or those not facing reproductive challenges may not benefit from this research.
What this research studies
This research investigates the role of the BRCA2 protein in the process of meiosis, which is crucial for producing sperm and eggs. By using advanced genetic and biochemical techniques, the study aims to uncover how BRCA2 contributes to DNA repair and chromosome segregation during this specialized cell division. The researchers will develop new tools to analyze BRCA2's functions and interactions, providing insights into its importance in gamete quality. This knowledge could help improve reproductive health and cancer risk assessment.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of reproductive health issues and breast cancer risk in individuals with BRCA2 mutations.
How similar studies have gone: Previous research has shown that understanding the mechanisms of BRCA2 in DNA repair can lead to significant advancements in cancer treatment and reproductive health, indicating a promising avenue for this study.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Hunter, Neil — University of California at Davis
- Study coordinator: Hunter, Neil
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.