Understanding how BRCA1 helps repair DNA damage
Project 1: Recruitment of the BRCA1-associated Homologous Recombination Machinery
['FUNDING_P01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-11080257
This study is looking at how a protein called BRCA1 helps fix damaged DNA, which is important for understanding and improving treatments for certain cancers that can happen when BRCA1 isn't working properly.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11080257 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the BRCA1 protein in the process of DNA repair, particularly how it is recruited to sites of DNA damage. By examining the interactions between BRCA1 and other proteins like BARD1, the study aims to clarify the mechanisms that control BRCA1's function in repairing DNA. The research utilizes advanced mouse models to explore these interactions and their implications for cancer treatment. Patients may benefit from insights that could lead to new therapies for cancers associated with BRCA1 deficiencies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with known BRCA1 mutations or those diagnosed with breast cancer associated with BRCA1 deficiencies.
Not a fit: Patients without BRCA1 mutations or those with unrelated cancer types may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for breast and other cancers linked to BRCA1 mutations.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, making this approach a continuation of established scientific inquiry.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUNTING, SAMUEL — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: BUNTING, SAMUEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.