Understanding how BRCA1 and BARD1 proteins help repair DNA damage
Official title: The Mechanistic Role of BRCA1-BARD1 DNA and RAD51 Binding in DNA Double-Strand Break Repair
Funded at University of Texas Hlth Science Center · NIH-11082992 · Data updated 2026-11-12
This study is looking at how two proteins, BRCA1 and BARD1, help fix broken DNA, which is really important for keeping our genes healthy, and it could help people with breast and ovarian cancer understand how problems with these proteins might affect their treatment.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $47,780 |
| NIH project number | 5F30CA278370-03 |
| Project ID | NIH-11082992 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with a family history of breast or ovarian cancer, particularly those with known mutations in the BRCA1 or BARD1 genes.
✕Less likely to help
Patients without a genetic predisposition to breast or ovarian cancer or those with unrelated cancer types may not receive direct benefits from this research.
What this research studies
This research investigates the roles of the BRCA1 and BARD1 proteins in repairing DNA double-strand breaks, which are critical for maintaining genomic stability. By examining how these proteins interact with DNA and the RAD51 recombinase, the study aims to uncover the mechanisms that enable effective DNA repair. The approach involves biochemical experiments and cell-based studies to explore the functions of these proteins in the context of cancer biology, particularly in breast and ovarian cancers. Patients may benefit from insights gained into how defects in these proteins contribute to cancer development and treatment resistance.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cancer mechanisms and potential new therapeutic strategies for patients with BRCA1 and BARD1-related cancers.
How similar studies have gone: Previous research has shown that understanding the roles of DNA repair proteins like BRCA1 and BARD1 can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Jasper, Angela Mary — University of Texas Hlth Science Center
- Study coordinator: Jasper, Angela Mary
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.