Understanding how BRCA1 affects DNA repair in cancer cells
Official title: Project 2: BRCA1-dependent DNA End Resection and Regulation via the 53BP1 Axis
Funded at University of Texas Hlth Science Center · NIH-10847789 · Data updated 2026-11-12
This study looks at how the BRCA1 protein helps fix DNA damage in cells, especially in breast cancer, to understand why some cancer cells resist treatment, with the hope of finding better therapies for patients with BRCA1-related cancers.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $541,923 |
| NIH project number | 1P01CA275717-01A1 |
| Project ID | NIH-10847789 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with BRCA1 mutations or those diagnosed with BRCA1-related breast or ovarian cancers.
✕Less likely to help
Patients without BRCA1 mutations or those with cancers unrelated to BRCA1 may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the BRCA1 protein influences the repair of DNA damage in cells, particularly in the context of breast cancer. It focuses on how BRCA1 interacts with other proteins to regulate DNA repair pathways, which are crucial for maintaining genomic stability. By studying these interactions, the research aims to uncover why certain cancer cells become resistant to treatments that target DNA repair processes. Patients may benefit from insights that could lead to more effective therapies for BRCA1-related cancers.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with BRCA1-related cancers, potentially enhancing their response to therapies.
How similar studies have gone: Previous research has shown that targeting DNA repair mechanisms in BRCA1-deficient tumors can lead to successful treatment outcomes, indicating a promising avenue for further exploration.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Burma, Sandeep — University of Texas Hlth Science Center
- Study coordinator: Burma, Sandeep
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.