Understanding how BRCA-related proteins affect cancer development and treatment response
Mechanisms of the BRCA-network in tumorigenesis and therapeutic response
['FUNDING_P01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-11080256
This study is looking at how certain proteins help keep our DNA healthy and how problems with these proteins can lead to cancer, with the goal of finding new ways to treat the disease.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11080256 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the BRCA protein network in maintaining DNA integrity and how defects in this network can lead to cancer. By examining the mechanisms of DNA repair and the vulnerabilities of tumors, the research aims to identify new therapeutic strategies that exploit these weaknesses. The team employs a multidisciplinary approach, focusing on various proteins involved in DNA repair, to uncover how they interact and influence cancer progression and treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with breast or ovarian cancer who have BRCA1 or BRCA2 mutations.
Not a fit: Patients without BRCA mutations or those with cancers unrelated to BRCA-related pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer therapies that specifically target vulnerabilities in tumors with BRCA mutations.
How similar studies have performed: Previous research has shown promising results in targeting DNA repair mechanisms in cancers associated with BRCA mutations, indicating a potential for success in this area.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHEN, ZHIYUAN — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: SHEN, ZHIYUAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy