Understanding how BRCA-related DNA repair works
Official title: Regulation of BRCA-dependent Genome Repair via the 53BP1 Axis
Funded at University of Texas Hlth Science Center · NIH-10847786 · Data updated 2026-11-12
This study is looking at how our cells fix damaged DNA and how certain proteins help with this process, which could lead to new treatments for people with BRCA-related cancer risks.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,556,071 |
| NIH project number | 1P01CA275717-01A1 |
| Project ID | NIH-10847786 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with BRCA1 or BRCA2 mutations, particularly those diagnosed with breast or other related cancers.
✕Less likely to help
Patients without BRCA mutations or those not diagnosed with related cancers may not benefit from this research.
What this research studies
This research investigates the mechanisms behind DNA repair processes, particularly focusing on how certain proteins influence the repair of DNA damage in cells. It aims to understand the balance between two main repair pathways, which can affect the stability of the genome and the risk of cancer development. By studying these processes, the research seeks to identify potential targets for new anti-cancer therapies that could improve treatment outcomes for patients with BRCA deficiencies.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments for patients with BRCA-related genetic vulnerabilities.
How similar studies have gone: Previous research has shown promising results in understanding DNA repair mechanisms, suggesting that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Sung, Patrick — University of Texas Hlth Science Center
- Study coordinator: Sung, Patrick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.