Understanding how BRCA mutations affect cancer treatment response
Defining BRCA replication dysfunction in therapy response
This study is looking at how tumors with BRCA gene mutations react to cancer treatments, aiming to understand why some respond well while others don't, which could help doctors find better ways to predict and improve treatment for patients with these types of tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11095814 on NIH RePORTER |
What this research studies
This research investigates how tumors with mutations in the BRCA genes respond to cancer therapies. It focuses on the role of DNA replication stress and the formation of single-stranded DNA gaps in cancer cells. By employing advanced experimental techniques, the study aims to identify the mechanisms that lead to therapy sensitivity and resistance in BRCA-deficient tumors. The findings could help develop biomarkers for predicting treatment outcomes and strategies to overcome resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with breast or ovarian cancers associated with BRCA1 or BRCA2 mutations.
Not a fit: Patients without BRCA mutations or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with BRCA-related cancers.
How similar studies have performed: Other research has shown promising results in understanding cancer treatment responses related to DNA repair mechanisms, making this approach both relevant and potentially impactful.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Cantor, Sharon B — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Cantor, Sharon B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.