Understanding how BRCA genes help repair DNA damage
Genome Maintenance via the BRCA-RAD54 Axis
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · NIH-11034071
This study is looking at how certain proteins, like BRCA1 and BRCA2, help fix DNA damage in our cells, which is really important for keeping us healthy, especially for people with a family history of breast and ovarian cancers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCIENCE CENTER (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-11034071 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which BRCA1, BRCA2, and associated proteins work together to repair DNA damage in human cells. By using advanced techniques in biochemistry and biophysics, the study aims to uncover how these proteins interact during the DNA repair process, which is crucial for maintaining genomic stability. Patients may benefit from insights gained about these mechanisms, particularly those with genetic predispositions to breast and ovarian cancers. The research seeks to fill existing knowledge gaps in how these proteins function in humans compared to simpler organisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with mutations in BRCA1 or BRCA2 genes, particularly those with a family history of breast or ovarian cancer.
Not a fit: Patients without BRCA mutations or those with cancers unrelated to DNA repair mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of DNA repair processes, potentially informing new treatments for patients with BRCA-related cancers.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms in simpler organisms, but this specific approach in humans is relatively novel.
Where this research is happening
SAN ANTONIO, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCIENCE CENTER — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHAO, WEIXING WILSON — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- Study coordinator: ZHAO, WEIXING WILSON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.