Understanding how branched-chain fatty acids affect Staphylococcus aureus
Role of branched-chain fatty acids in physiology and virulence of Staphylococcus aureus
['FUNDING_OTHER'] · GEORGETOWN UNIVERSITY · NIH-11125020
This study is looking at how certain fatty acids affect the behavior of Staphylococcus aureus, a common germ that can cause infections, to help us understand how it fights against our immune system and how we might find better ways to treat these infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGETOWN UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-11125020 on ClinicalTrials.gov |
What this research studies
This research investigates the role of branched-chain fatty acids in the physiology and virulence of Staphylococcus aureus, a common bacterial pathogen. The study focuses on how these fatty acids influence the bacteria's ability to respond to the host's immune system and regulate its virulence factors. By examining the mechanisms of two-component systems that help the bacteria adapt to hostile environments, the research aims to uncover new insights into bacterial metabolism and pathogenesis. This could lead to better strategies for combating infections caused by Staphylococcus aureus.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with infections caused by Staphylococcus aureus, particularly those with antibiotic-resistant strains.
Not a fit: Patients with infections caused by other types of bacteria or those without bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the effectiveness of antibiotics against Staphylococcus aureus infections.
How similar studies have performed: Previous research has shown success in understanding bacterial responses to host defenses, indicating that this approach has potential for meaningful advancements.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGETOWN UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRINSMADE, SHAUN R — GEORGETOWN UNIVERSITY
- Study coordinator: BRINSMADE, SHAUN R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.