Understanding how brainstem neurons control sleep
Brainstem circuitry for sleep-wake control
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-10849891
This study is looking at certain brain cells that help control our sleep and wakefulness, especially how they can encourage deep, restful sleep, with the hope of finding new ways to help people who have trouble sleeping.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-10849891 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific neurons in the brainstem that regulate sleep-wake cycles, particularly focusing on a group of neurons known as parafacial zone (PZ) GABAergic neurons. By examining how these neurons promote deep, restorative sleep, the research aims to fill a critical gap in our understanding of sleep regulation. The approach involves detailed cellular and synaptic studies to uncover the mechanisms by which these neurons influence sleep patterns. Ultimately, the goal is to develop new strategies for treating sleep disorders by manipulating these sleep-promoting circuits.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing sleep-wake disorders or poor sleep quality.
Not a fit: Patients with sleep disorders unrelated to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of safer and more effective treatments for sleep disorders.
How similar studies have performed: Other research has shown promising results in understanding sleep regulation through neuronal mechanisms, indicating potential for success in this area.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANACLET, CHRISTELLE — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: ANACLET, CHRISTELLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.