Understanding how brainstem neurons control heart health through the vagus nerve
Molecular Neurogenetics of the Brainstem Neuronal Source of Cardioprotective Vagal Outflow
['FUNDING_R01'] · THOMAS JEFFERSON UNIVERSITY · NIH-10863852
This study is looking at how certain brain cells help control the vagus nerve, which is important for keeping your heart healthy, and it aims to find ways to improve heart protection by understanding how these cells respond to heart signals.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | THOMAS JEFFERSON UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10863852 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific brainstem neurons in regulating the vagus nerve, which is crucial for heart health. By studying the dorsal motor nucleus of the vagus, the researchers aim to identify how these neurons respond to signals related to heart function. They will analyze molecular mechanisms involved in vagal outflow, which could help in developing interventions to enhance heart protection. The approach combines experimental techniques with computational analysis to understand the genetic factors at play.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for heart disease or those with existing cardiovascular conditions.
Not a fit: Patients with non-cardiovascular related health issues or those not experiencing heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and reversing heart disease by enhancing vagal nerve activity.
How similar studies have performed: Previous research has shown success in similar approaches, particularly in understanding microRNA regulation related to hypertension.
Where this research is happening
PHILADELPHIA, UNITED STATES
- THOMAS JEFFERSON UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHWABER, JAMES — THOMAS JEFFERSON UNIVERSITY
- Study coordinator: SCHWABER, JAMES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiac Diseases