Understanding how brainstem neurons affect breathing and sudden death in epilepsy
Role of brainstem cardiorespiratory neurons in SUDEP
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-11004250
This study is looking at how certain brain cells might cause Sudden Unexpected Death in Epilepsy (SUDEP) during seizures, especially in people with a specific genetic condition, and aims to find ways to help prevent this serious risk for those living with epilepsy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-11004250 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific brainstem neurons in the occurrence of Sudden Unexpected Death in Epilepsy (SUDEP), which is a critical concern for individuals with epilepsy. By using mouse models that mimic the genetic mutations found in patients with SCN8A epileptic encephalopathy, the study aims to explore how breathing cessation during seizures leads to respiratory failure and death. The researchers will analyze the mechanisms of respiratory dysfunction and seek to develop potential rescue therapies to prevent SUDEP. This work is crucial for improving the safety and outcomes for patients with epilepsy.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with epilepsy, particularly those with SCN8A mutations or those who have experienced seizures.
Not a fit: Patients without epilepsy or those whose seizures are well-controlled and do not pose a risk for SUDEP may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent SUDEP, significantly improving the safety of patients with epilepsy.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of SUDEP, but this specific approach using mouse models is relatively novel.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PATEL, MANOJ K — UNIVERSITY OF VIRGINIA
- Study coordinator: PATEL, MANOJ K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: breathing disorder