Understanding How Brain Tumors Spread
Plexin-B2 Function in Glioma Invasion
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11141159
This research looks into how glioblastoma brain tumors move and spread throughout the brain, hoping to find new ways to stop them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11141159 on ClinicalTrials.gov |
What this research studies
Glioblastoma (GBM) is a very aggressive brain tumor known for its ability to spread rapidly into surrounding brain tissue. We are learning more about how these tumor cells navigate the physical environment of the brain, but the exact ways they gain this invasive ability are not fully understood. This project focuses on specific proteins called Plexin-B2 and Plexin-D1, which appear to be highly active in GBM and linked to poorer patient survival. Our goal is to discover how these Plexin proteins help GBM cells move and overcome the resistance of stiffer brain tissue, which is a key challenge in preventing tumor spread.
Who could benefit from this research
Good fit: Patients diagnosed with glioblastoma, particularly those facing challenges with tumor invasion, are the ultimate focus of this foundational research.
Not a fit: Patients with other types of brain tumors or conditions not related to glioblastoma may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that specifically target and block the spread of glioblastoma, potentially improving patient outcomes and quality of life.
How similar studies have performed: This project builds upon exciting recent discoveries and preliminary data from patient-derived cells, suggesting that Plexin proteins play a crucial role in glioblastoma cell movement.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRIEDEL, ROLAND HORST — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: FRIEDEL, ROLAND HORST
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.