Understanding how brain tumors resist treatment
Molecular Mechanisms of Drug Resistance in Primary Brain Tumors
['FUNDING_OTHER'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10991836
This study is looking into why some brain tumors, like low-grade gliomas and glioblastomas, don’t respond well to treatment, and it hopes to find new, personalized therapies that can help patients based on the specific genetic changes in their tumors.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10991836 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms behind drug resistance in primary brain tumors, focusing on specific genetic alterations that affect treatment outcomes. By analyzing tumor biopsies from patients and using experimental models, the research aims to identify critical genetic changes in tumor types such as low-grade gliomas and glioblastomas. The goal is to develop targeted therapies that can effectively combat these tumors and improve patient outcomes. Patients may benefit from new treatment strategies that are tailored to the genetic profile of their tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults diagnosed with primary brain tumors, particularly those with specific genetic alterations like IDH mutations or BTK involvement.
Not a fit: Patients with brain tumors that do not have the targeted genetic alterations being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with primary brain tumors, potentially improving survival rates and quality of life.
How similar studies have performed: Previous research has shown promise in targeting specific genetic alterations in other cancers, suggesting that this approach could be beneficial for brain tumors as well.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MELLINGHOFF, INGO K — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: MELLINGHOFF, INGO K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.