Understanding how brain tumors hide from the immune system
IDO1 and Immunotolerance in Glioblastoma
This research explores how a specific protein, IDO1, helps glioblastoma brain tumors avoid being attacked by the body's immune system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project ID | NIH-11127447 on NIH RePORTER |
What this research studies
Glioblastoma is a very aggressive brain tumor, and it often finds ways to protect itself from the body's natural defenses. This project looks closely at a protein called IDO1, which is found in most glioblastoma tumors. IDO1 works by suppressing the immune system, making it harder for immune cells to fight the cancer. By understanding how IDO1 helps tumors hide, we hope to find new ways to make immune-based treatments more effective against glioblastoma.
Who could benefit from this research
Good fit: This research is relevant for adult patients diagnosed with glioblastoma, particularly those whose tumors express the IDO1 protein.
Not a fit: Patients with other types of brain tumors or cancers that do not involve IDO1 may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help the immune system better fight glioblastoma, potentially improving patient outcomes.
How similar studies have performed: This project builds upon extensive prior work by the principal investigator and others, suggesting a strong foundation for this approach in understanding glioblastoma immunology.
Where this research is happening
Maywood, United States
- Loyola University Chicago — Maywood, United States (Active)
Researchers
- Principal investigator: Wainwright, Derek Alan — Loyola University Chicago
- Study coordinator: Wainwright, Derek Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.