Understanding how brain tumors evolve and become resistant to treatment
The Immortality and Evolution of Adult Brain Tumors
This study is looking at how brain tumors grow and become resistant to treatments, so we can find better ways to personalize immunotherapy for patients with brain tumors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10917101 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the immortality and evolution of brain tumors, focusing on how these tumors develop resistance to therapies. By utilizing a unique 3-dimensional sampling approach, the team collects multiple spatially mapped samples from each tumor to analyze genetic and immune characteristics. The goal is to identify specific mutations that create neoantigens, which can be targeted for personalized immunotherapy. This work aims to improve treatment outcomes for patients with brain tumors by addressing the challenges posed by tumor heterogeneity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with brain tumors, particularly those who are 21 years or older.
Not a fit: Patients with non-brain tumor cancers or those under 21 years of age may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective personalized immunotherapies for patients with brain tumors.
How similar studies have performed: Other research has shown promise in using similar approaches to target tumor heterogeneity and improve immunotherapy outcomes, indicating a potential for success in this area.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Hong, Chibo — University of California, San Francisco
- Study coordinator: Hong, Chibo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.