Understanding how brain tumors adapt to targeted therapies
Brain microenviornment-dependent lineage plasticity drives adaptation to targeted therapy in malignant gliomas
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10997865
This study is looking at how brain tumors called gliomas change and resist treatment, with the goal of finding better and more personalized ways to help patients with this type of cancer.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10997865 on ClinicalTrials.gov |
What this research studies
This research investigates how malignant gliomas, a common and deadly type of brain cancer, adapt to targeted therapies. By examining the brain's unique environment, the study aims to uncover the mechanisms that allow these tumors to resist treatment. Using advanced techniques like single-cell RNA sequencing and genetic tracing, researchers will analyze how tumor cells change their characteristics in response to therapy. This could lead to more effective and personalized treatment strategies for patients with glioblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with malignant gliomas, particularly those who have not responded well to existing therapies.
Not a fit: Patients with non-malignant brain tumors or those who are not diagnosed with gliomas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with malignant gliomas, potentially increasing survival rates.
How similar studies have performed: Previous research has shown promising results in understanding tumor plasticity and resistance mechanisms in other cancers, suggesting potential for success in this area as well.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CADET, DIMITRI — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: CADET, DIMITRI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.