Understanding how brain swelling affects nerve cell activity after brain injury
The dynamic balance between neuronal volume and chloride handling in network excitability after traumatic brain injury
This study is looking at how brain swelling after a head injury affects brain activity, with the hope of finding new ways to help people recover from traumatic brain injuries, whether they are mild or severe.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project ID | NIH-11062621 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind cerebral edema, which is swelling in the brain that can occur after a traumatic brain injury (TBI). The team will explore how this swelling impacts the excitability of neurons and brain networks, particularly focusing on changes in a specific transporter that regulates chloride levels in nerve cells. By using advanced imaging techniques, they aim to uncover the relationship between neuronal swelling and changes in brain activity, which could lead to new treatment strategies for TBI. The study will analyze both mild and severe injuries to provide a comprehensive understanding of the condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced a traumatic brain injury, whether mild or severe.
Not a fit: Patients with brain injuries that are not related to cerebral edema may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from the effects of traumatic brain injury.
How similar studies have performed: Previous research has shown promising results in understanding the effects of edema on neuronal function, suggesting that this approach could yield valuable insights.
Where this research is happening
College Station, United States
- Texas A&m University Health Science Ctr — College Station, United States (Active)
Researchers
- Principal investigator: Pokam, Punam Adhik — Texas A&m University Health Science Ctr
- Study coordinator: Pokam, Punam Adhik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.