Understanding how brain support cells help neurons manage protein issues as we age
The role of glia in monitoring neuronal proteostasis in aging
This study is looking at how special brain cells help protect neurons from problems caused by misfolded proteins as we age, which could lead to better ways to support brain health in older adults, especially those at risk for Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10891464 on NIH RePORTER |
What this research studies
This research investigates the role of glial cells, which support neurons in the brain, in managing protein misfolding that occurs during aging and neurodegenerative diseases like Alzheimer's. The study uses the model organism C. elegans to explore how these glial cells communicate with neurons when they experience stress from misfolded proteins. By examining the signaling pathways involved, the research aims to uncover potential mechanisms that could enhance cellular health and longevity. This could lead to new insights into how to support brain health in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or other neurodegenerative conditions related to aging.
Not a fit: Patients with acute neurological conditions unrelated to aging or protein misfolding may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating neurodegenerative diseases by enhancing the brain's ability to manage protein misfolding.
How similar studies have performed: Previous research has shown promising results in understanding cellular responses to protein misfolding, but this specific approach focusing on glial signaling in aging is relatively novel.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Gildea, Holly Katherine — New York University School of Medicine
- Study coordinator: Gildea, Holly Katherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.