Understanding how brain structure affects learning and memory.
Elucidating the Role of Brain Extracellular Matrix in Hippocampal Learning and Memory
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11120942
This study is looking at how a protein called aggrecan in the brain helps us learn and remember things, especially in a part of the brain called the hippocampus, and it’s for anyone interested in understanding how our memories work and what keeps them strong over time.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11120942 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the brain's extracellular matrix, particularly a protein called aggrecan, in learning and memory processes. It focuses on how changes in this matrix can influence the brain's ability to form and retrieve memories, especially in the hippocampus, a key area for learning. The study will explore how the expression of aggrecan is affected by learning experiences and whether its presence is crucial for maintaining memory accuracy over time. By using genetic techniques, researchers aim to determine the importance of aggrecan in memory formation and retrieval.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are interested in understanding the biological basis of learning and memory.
Not a fit: Patients with severe neurological disorders that significantly impair cognitive function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into memory disorders and potential therapeutic strategies for improving memory function.
How similar studies have performed: Previous research has shown promising results regarding the role of the extracellular matrix in brain function, indicating that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUAJARDO, RICARDO — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: GUAJARDO, RICARDO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.