Understanding how brain stimulation can improve treatment for Parkinson's disease
Official title: Characterizing Evoked Potentials of Deep Brain Stimulation for Parkinson's Disease
Funded at Duke University · NIH-11009058 · Data updated 2026-11-12
This study is looking at how to make deep brain stimulation surgery for Parkinson's disease better by using special signals to help doctors place the stimulation leads more accurately, which could lead to quicker and more effective treatments for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $42,127 |
| NIH project number | 5F31NS130997-03 |
| Project ID | NIH-11009058 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Parkinson's disease who are considering deep brain stimulation as a treatment option.
✕Less likely to help
Patients who are not candidates for deep brain stimulation or those with advanced Parkinson's disease may not benefit from this research.
What this research studies
This research investigates deep brain stimulation (DBS) as a surgical treatment for Parkinson's disease, focusing on improving the placement of DBS leads to enhance patient outcomes. The study aims to use evoked potentials (EPs) as biomarkers to guide the precise placement of these leads, potentially allowing for faster and more accurate procedures. By examining how stimulation amplitude, lead location, and anesthesia affect EPs, the research seeks to correlate these factors with symptom relief. This could lead to a more efficient DBS process, possibly even allowing for procedures to be performed under anesthesia.
Why it matters
Potential benefit: If successful, this research could lead to improved surgical outcomes and reduced symptoms for patients with Parkinson's disease.
How similar studies have gone: Previous research has shown promise in using biomarkers for improving surgical outcomes in various neurological procedures, suggesting potential success for this approach.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Dale, Jahrane Antonio — Duke University
- Study coordinator: Dale, Jahrane Antonio
Related research
Other NIH-funded projects on the same topics.
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TinyML-powered closed-loop DBS for Parkinson's disease
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Adaptive Deep Brain Stimulation for Parkinson's Disease
A safety-focused study tests a new brain-stimulation device that could tailor therapy for people with Parkinson’s by adapting stimulation based on brain signals and sleep stages.
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Theta Burst Deep Brain Stimulation for Cognitive and Motor Benefits in Parkinson’s-Related Dementia
A study from USC will test a new brain stimulation approach to help people with Parkinson’s disease and Lewy body dementia improve thinking skills and movement.
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Spatiotemporal Tuning of Deep Brain Stimulation for Parkinson’s Disease
Aims to personalize deep brain stimulation by adjusting where and when the brain is stimulated to better control Parkinson’s symptoms.
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Understanding sleep problems in Parkinson’s disease using at-home brain recordings and adaptive stimulation
Scientists are testing how brain signals during sleep relate to sleep problems in Parkinson’s and whether a special DBS device at home can improve sleep by adapting stimulation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.