Understanding how brain stimulation can improve recovery after stroke
Calcium imaging-based insights and guidance of deep brain stimulation to enhance chronic, post-stroke rehabilitation in a rodent model of ischemia
This study is looking at how to make deep brain stimulation (DBS) work better for people recovering from strokes by testing it on rats, so we can find out why some people improve more than others and create personalized treatments for future patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10979483 on NIH RePORTER |
What this research studies
This research investigates how deep brain stimulation (DBS) can be customized to enhance rehabilitation for individuals recovering from strokes. By using a rat model, the team will explore how different DBS parameters affect brain recovery and reorganization after injury. The study aims to identify why some patients respond better to DBS than others, with the goal of developing personalized treatment approaches that could be translated to human patients in the future.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a stroke and are facing chronic motor deficits.
Not a fit: Patients who have not suffered a stroke or those with acute stroke conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective rehabilitation strategies for stroke survivors, improving their recovery outcomes.
How similar studies have performed: Other research has shown promising results with deep brain stimulation for rehabilitation, indicating potential for success in this approach.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Dana, Hod Michael — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Dana, Hod Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.