Understanding how brain stimulation affects walking in Parkinson's patients
Imaging Biomarkers of Freezing of Gait Response to Deep Brain Stimulation
This study is looking at how deep brain stimulation can help people with advanced Parkinson's disease who experience freezing of gait, and it aims to understand how the brain's connections affect the treatment's success.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10801555 on NIH RePORTER |
What this research studies
This research investigates the effects of deep brain stimulation (DBS) on freezing of gait (FOG) in patients with advanced Parkinson's disease. Using advanced diffusion MRI techniques, the study aims to explore the brain's structural connections and how they relate to the effectiveness of DBS. By comparing responses between patients who benefit from the treatment and those who do not, the research seeks to identify factors that could enhance the effectiveness of DBS over time. Patients selected for DBS surgery will undergo imaging and behavioral assessments to gather comprehensive data.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with advanced Parkinson's disease who are selected to undergo deep brain stimulation surgery.
Not a fit: Patients with early-stage Parkinson's disease or those not eligible for deep brain stimulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for freezing of gait in Parkinson's patients, enhancing their mobility and quality of life.
How similar studies have performed: Previous research has shown promising results in using neuroimaging to understand brain responses to deep brain stimulation, indicating that this approach could yield valuable insights.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Revuelta, Gonzalo Javier — Medical University of South Carolina
- Study coordinator: Revuelta, Gonzalo Javier
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.