Understanding how brain stimulation affects long-lasting motor responses in Parkinson's disease
Official title: Neural Substrates of the long-duration response
Funded at New York University School of Medicine · NIH-10987621 · Data updated 2026-11-12
This study is looking at how special brain stimulation can help people with Parkinson's disease move better for a longer time, using new techniques to understand how this works and find better treatment options.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $466,125 |
| NIH project number | 1R21NS137136-01A1 |
| Project ID | NIH-10987621 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease who experience motor response fluctuations.
✕Less likely to help
Patients who do not have Parkinson's disease or those who do not experience motor response issues may not benefit from this research.
What this research studies
This research investigates the long-duration response (LDR) in Parkinson's disease, focusing on how specific brain stimulation can improve motor function over extended periods. The study utilizes optogenetic techniques to stimulate certain neurons in the brain, aiming to understand the mechanisms that lead to sustained motor benefits. By exploring the relationship between brain activity and motor performance, the research seeks to identify new therapeutic strategies that could enhance the effectiveness of existing treatments for Parkinson's disease.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies that significantly reduce motor response 'wearing-off' in Parkinson's disease patients.
How similar studies have gone: Previous research has shown promising results with similar optogenetic approaches in animal models, indicating potential for success in this area.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Kang, Un Jung — New York University School of Medicine
- Study coordinator: Kang, Un Jung
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.