Understanding how brain signals influence jaw development
Transcriptional regulatory landscapes underlying FEZ Formation
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10793524
This study is looking at how signals from the brain help shape the upper jaw in birds, which could help us understand jaw development issues that some people are born with.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10793524 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between brain signals and neural crest cells that regulate the development of the upper jaw in vertebrates. By focusing on the Frontonasal Ectodermal Zone (FEZ), the study aims to uncover the genetic mechanisms that control the expression of Sonic hedgehog (SHH), a crucial signaling molecule for jaw formation. The researchers will utilize avian models, specifically chicken embryos, to explore how transcription factors influence SHH expression and the overall morphogenesis of the jaw. This work could provide insights into congenital defects affecting jaw development.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with congenital jaw abnormalities or birth defects related to jaw formation.
Not a fit: Patients with jaw conditions unrelated to developmental signaling pathways may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for congenital jaw deformities.
How similar studies have performed: Other research has shown success in understanding genetic mechanisms of development, making this approach promising but still exploratory.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARCUCIO, RALPH S — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: MARCUCIO, RALPH S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.