Understanding how brain signals control weight differently in men and women
Uncovering the role of hypothalamic ciliary cAMP signaling in sex-specific control of metabolic homeostasis
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-11131095
This project aims to understand how specific brain signals in the hypothalamus contribute to differences in weight gain between men and women.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-11131095 on ClinicalTrials.gov |
What this research studies
We know that obesity affects men and women differently, but the exact brain mechanisms are unclear. This project focuses on a part of the brain called the hypothalamus, which is vital for controlling energy balance. Researchers are looking at tiny, antenna-like structures on brain cells, called primary cilia, and a specific gene called Adcy3, which has been linked to obesity in humans and animals, especially in females. By studying how these cilia and Adcy3 work in the hypothalamus, particularly in female mice, we hope to uncover why weight gain patterns differ by sex.
Who could benefit from this research
Good fit: This foundational research is relevant for individuals with obesity, particularly women, who may benefit from future targeted therapies.
Not a fit: Patients who do not have obesity or related metabolic conditions may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new, sex-specific treatments for obesity by targeting these unique brain pathways.
How similar studies have performed: Previous human genetic studies and animal research have already linked the Adcy3 gene and primary cilia to obesity, especially in females, providing a strong foundation for this work.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CUI, HUXING — UNIVERSITY OF IOWA
- Study coordinator: CUI, HUXING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.