Understanding how brain signals can improve bone health
Rejuvenating Skeletal Health Through A Novel Brain-Bone Axis
This study is looking at how the brain talks to our bones to find new ways to keep bones healthy as we age, which could help people with age-related bone loss.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11116884 on NIH RePORTER |
What this research studies
This research investigates the communication between the brain and bones to find ways to enhance bone health, particularly in aging individuals. By studying specific neurons in the brain that influence bone mass and fat, the researchers aim to identify factors that can promote bone growth while reducing fat in the bones. The approach involves advanced genetic techniques and animal models to uncover the mechanisms behind these interactions. Patients may benefit from insights that could lead to new treatments for age-related bone loss.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related bone loss or those at risk for osteoporosis.
Not a fit: Patients with acute bone injuries or those with conditions unrelated to bone health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve bone density and reduce the risk of fractures in older adults.
How similar studies have performed: Previous studies have shown promising results in understanding brain-bone interactions, but this specific approach is novel and untested.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Ingraham, Holly a. — University of California, San Francisco
- Study coordinator: Ingraham, Holly a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.