Understanding how brain signals can help recover patients from coma

Who could benefit from this research

What this research studies

This research investigates the mechanisms that support recovery from acute coma, particularly focusing on the role of neuro-glio-vascular restoration. Using a rat model of brainstem coma, the study aims to explore how specific brain circuits, particularly the thalamocortical circuit, can be activated to promote recovery. By employing advanced techniques like multi-modal fMRI and calcium recordings, researchers will analyze how astrocytes and other brain cells contribute to recovery during critical early hours after injury. This work seeks to uncover new therapeutic targets that could improve outcomes for patients who have suffered severe brain injuries.

Why it matters

Where this research is happening

• Massachusetts General Hospital
  Boston, United States Active

Researchers

• Principal investigator: Yu, Xin — Massachusetts General Hospital
• Study coordinator: Yu, Xin

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.