Understanding how brain signals affect withdrawal symptoms from opioids like fentanyl
Aversive midbrain glutamatergic regulation of the locus coeruleus during opioid withdrawal
This study is looking at how a part of the brain helps manage withdrawal symptoms from synthetic opioids like fentanyl, and it aims to find new ways to make the tough feelings and physical discomfort of withdrawal easier to handle.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10993429 on NIH RePORTER |
What this research studies
This research investigates the role of a specific brain system in managing withdrawal symptoms from synthetic opioids, particularly fentanyl. It focuses on how glutamate, a neurotransmitter, influences the activity of noradrenergic neurons in the locus coeruleus during opioid withdrawal. By studying this interaction, the research aims to uncover potential new treatments for alleviating negative emotional and physical effects experienced during withdrawal. The approach involves advanced techniques to analyze brain activity and neurotransmitter levels in animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing withdrawal symptoms from opioid use, particularly those using synthetic opioids like fentanyl.
Not a fit: Patients who are not currently experiencing opioid withdrawal or who have not used opioids may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the distress and discomfort associated with opioid withdrawal.
How similar studies have performed: Previous research has shown that understanding brain mechanisms involved in withdrawal can lead to effective treatments, suggesting this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Mccall, Jordan G. — Washington University
- Study coordinator: Mccall, Jordan G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.