Understanding how brain signals affect binge eating behavior
Investigating the role of nucleus accumbens delta signaling in loss of control
This study is looking at how brain signals in a part of the brain linked to rewards affect people with binge eating disorder, and it’s testing a new treatment that involves a small device implanted in the brain to help reduce episodes of overeating and improve eating habits.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11015853 on NIH RePORTER |
What this research studies
This research investigates the role of brain signaling in the nucleus accumbens, a region associated with reward and control, in individuals with binge eating disorder. By utilizing data from a trial involving responsive neurostimulation, the study aims to assess the safety and effectiveness of this treatment in reducing episodes of loss of control eating. Participants will undergo a surgical procedure to implant a neurostimulation device that targets specific brain signals, with the goal of improving their eating behaviors. The research will also explore how these brain signals change in response to the treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who experience binge eating disorder and have a sense of loss of control over their eating.
Not a fit: Patients who do not have binge eating disorder or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for individuals struggling with binge eating disorder, helping them regain control over their eating habits.
How similar studies have performed: Preliminary data from similar studies using neurostimulation techniques have shown promise in reducing loss of control eating behaviors, indicating potential for success in this approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Halpern, Casey Harrison — University of Pennsylvania
- Study coordinator: Halpern, Casey Harrison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.