Understanding how brain signaling affects pain mechanisms
Trans-synaptic signaling complex in amygdala pain mechanisms
This study is looking at how certain brain receptors in the amygdala affect the way we feel and handle pain, with the hope of finding better treatments for people dealing with chronic pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project ID | NIH-10901899 on NIH RePORTER |
What this research studies
This research investigates the role of specific brain receptors in the amygdala that may influence how pain is processed and experienced. By examining the connections and signaling pathways in the brain, particularly focusing on the glutamate delta 1 receptor, the research aims to uncover new therapeutic targets for chronic pain management. The study will involve detailed analysis of how these receptors function and their impact on pain behaviors, which could lead to more effective treatments for patients suffering from persistent pain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic pain conditions, particularly those who have not found relief with existing treatments.
Not a fit: Patients with acute pain or those who do not experience chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel pain management therapies that are more effective and have fewer side effects than current medications.
How similar studies have performed: Other research has shown promise in targeting brain signaling pathways for pain management, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
College Station, United States
- Texas A&m University Health Science Ctr — College Station, United States (Active)
Researchers
- Principal investigator: Dravid, Shashank Manohar — Texas A&m University Health Science Ctr
- Study coordinator: Dravid, Shashank Manohar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.