Understanding how brain signaling affects learning and behavior
Discrete Functions of Basal Forebrain Cholinergic Signaling to Amygdala and Orbitofrontal Cortex in Reversal Learning
['FUNDING_CAREER'] · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · NIH-10985270
This study is looking at how certain brain signals affect learning and adapting behavior, especially for people with autism or schizophrenia, to find better ways to help improve their thinking and behavior.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10985270 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific brain signaling pathways in learning and behavioral flexibility, particularly in conditions like autism spectrum disorder and schizophrenia. It utilizes advanced techniques such as optogenetics and behavioral tracking to study how these pathways influence cognitive functions. By analyzing neural and behavioral data, the research aims to uncover mechanisms that could lead to improved treatments for cognitive impairments. The findings may help in developing targeted interventions for patients with these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, schizophrenia, or other cognitive dysfunctions.
Not a fit: Patients with cognitive impairments not related to the conditions being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance cognitive flexibility and improve adaptive behaviors in patients with autism and related disorders.
How similar studies have performed: Previous research has shown promising results in understanding brain signaling and its impact on learning, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VILLARIN, JOSEPH MANUEL — NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
- Study coordinator: VILLARIN, JOSEPH MANUEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.