Understanding how brain signaling affects epilepsy in children
Translational control in focal cortical malformations and epilepsy
This study is looking at how a specific brain condition in kids, called focal cortical dysplasia type II, affects their brain development and causes hard-to-treat seizures, with the hope of finding new ways to help them feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project ID | NIH-11105074 on NIH RePORTER |
What this research studies
This research investigates focal cortical dysplasia type II (FCDII), a condition in children that leads to brain malformations and seizures resistant to treatment. The study focuses on the mTOR signaling pathway and its role in abnormal brain development and seizure activity. By examining how specific proteins regulate the translation of important mRNAs, the research aims to uncover the mechanisms behind these brain abnormalities and their impact on epilepsy. This could lead to new insights into potential treatments for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years diagnosed with focal cortical dysplasia type II and experiencing seizures.
Not a fit: Patients with epilepsy not related to focal cortical dysplasia or those outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for children suffering from epilepsy caused by focal cortical dysplasia.
How similar studies have performed: Previous research has shown promising results in understanding the role of mTOR signaling in epilepsy, but the specific approach of this study is novel.
Where this research is happening
Richardson, United States
- University of Texas Dallas — Richardson, United States (Active)
Researchers
- Principal investigator: Nguyen, Lena — University of Texas Dallas
- Study coordinator: Nguyen, Lena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.