Understanding how brain regions interact during learning processes

Prefrontal-Hippocampal Interactions during Model-Based Learning

NIH-funded research University of California Berkeley · NIH-10902076

This study is looking at how two important parts of the brain, the prefrontal cortex and hippocampus, work together to help us learn and make decisions, especially in people with conditions like schizophrenia and depression, to find new ways to help improve their treatment.

Quick facts

Grant typeFellowship grant
Study typeNIH-funded research
Funding institutionUniversity of California Berkeley NIH-funded
Lab location1 site (Berkeley, United States)
Project IDNIH-10902076 on NIH RePORTER

What this research studies

This research investigates the interactions between the prefrontal cortex and hippocampus, two critical brain regions involved in learning and decision-making. By examining how these areas communicate, the study aims to uncover the neural mechanisms behind certain neuropsychiatric disorders like schizophrenia and depression. The researchers will utilize advanced techniques to analyze neuronal properties and their roles in reinforcement learning, which could lead to the development of new therapeutic devices. Ultimately, this work seeks to enhance our understanding of how the brain processes information and makes decisions.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals diagnosed with neuropsychiatric disorders such as schizophrenia, major depression, or PTSD.

Not a fit: Patients with neuropsychiatric disorders not involving dysfunction in the prefrontal cortex or hippocampus may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to innovative treatments for neuropsychiatric disorders by improving our understanding of brain function.

How similar studies have performed: Previous research has shown promising results in understanding brain interactions in learning, suggesting that this approach could yield valuable insights.

Where this research is happening

Berkeley, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.