Understanding how brain regions affect navigation in Alzheimer's disease models
Decoding Hippocampal-Parietal contributions to spatial navigation in a mouse modeling Tau and AB aggregation features of Alzheimer's Disease
['FUNDING_FELLOWSHIP'] · FLORIDA STATE UNIVERSITY · NIH-10873362
This study is looking at how two important parts of the brain work together when mice with Alzheimer's disease try to find their way around, and it hopes to see if helping these brain areas can make it easier for them to navigate, which could lead to new ways to help people with Alzheimer's.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FLORIDA STATE UNIVERSITY (nih funded) |
| Locations | 1 site (TALLAHASSEE, UNITED STATES) |
| Trial ID | NIH-10873362 on ClinicalTrials.gov |
What this research studies
This research investigates how the hippocampus and parietal cortex interact during spatial navigation in mouse models of Alzheimer's disease. It focuses on understanding early symptoms of Alzheimer's, particularly impairments in navigation, which may arise from issues in memory and cognitive processing. The study will explore whether stimulating these brain regions can improve navigation abilities in these mice, providing insights into potential therapeutic approaches for Alzheimer's. By examining these interactions, the research aims to enhance our understanding of the disease's progression and identify possible interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals at risk for Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for detecting and treating early symptoms of Alzheimer's disease.
How similar studies have performed: Previous research has shown that stimulating brain regions can improve cognitive functions in animal models, suggesting potential for success in this approach.
Where this research is happening
TALLAHASSEE, UNITED STATES
- FLORIDA STATE UNIVERSITY — TALLAHASSEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CUSHING, SARAH DANIELLE — FLORIDA STATE UNIVERSITY
- Study coordinator: CUSHING, SARAH DANIELLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome